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Variations in genes related to maintaining mitochondrial balance are strongly linked to the susceptibility to CD and its clinical progression

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Forbes J et al

Nearly one in four, 23% specifically, lost 30% or more of their body weight

The review would benefit from a bit more text on how this notion impacts the balance between desired therapeutic effects, "diluted" effects from dimer-mediated versus non-dimer effects, and undesired off-target effects (which are discussed some in terms of receptor specificity, but not in terms of anatomy, where the same dimer may have different effects in different brain regions). Response: We have added a new section title General treatment approaches before the concluding remarks