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21 , 23472358.e2346 (2023)

Enhancing Satiety and Reducing Appetite Prolonged Satiety: Semaglutides influence on satiety, when coupled with peptides targeting appetite-regulating pathways, can result in prolonged feelings of fullness

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial [published correction appears in Lancet

Great Britain

Kidney Problems : Dehydration from diarrhoea, nausea, or vomiting may worsen kidney issues

Musculoskeletal & Anti-Inflammatory Effects GLP-1 receptors are present in: Chondrocytes Synovial tissues Macrophages Potential benefits include: Reduced inflammatory cytokines NF-B inhibition Reduced cartilage degradation Improvement in osteoarthritis inflammation The anti-inflammatory role of GLP-1 may become clinically important in rheumatologic and degenerative diseases