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While other GH peptides work by raising growth hormone (which then raises IGF-1), this one skips the middleman and delivers IGF-1 directly

The original price comes from the large cost of drug development and clinical trials

The mechanism of action of GLP-1 receptor agonists does not depend on gallbladder function

Table of Contents Commonly Used Injection Sites for Retatrutide Retatrutide is injected subcutaneously into the abdomen (at least 5 cm from the navel), the anterolateral mid-thigh, or the outer upper arm, with all site guidance governed by the clinical trial protocol

#DDW2025 OBESITY AND IBD by @EdwardLoftus2 Obesity is a chronic inflammatory statue Adipose tissue is not biologically inert (TNFa, IL-6, IL-8, leptin, adiponectin) Postulated role in the pathogenesis of IBD Potential risk factor for adverse outcomes Trends in BMI among IBD patients at diagnosis in Olmsted County, Doubling of obesity rates in 20 years in CD and UC (Johnson AM JCC 2021 and J Clin Gastro 2024) Obese patients more likely to have a colonic phenotype

I do not obsess over meals anymore