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Therefore, injection frequency is far more crucial than the dose

Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial

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This process involves the activation of a cascade of caspase enzymes, particularly caspase-3, which executing apoptosis through the cleavage of key intracellular substrates

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Overall, we conclude that PC patients with low expression of VRK2 are sensitive to GSH-targeting therapy, while PC patients with high expression of VRK2 are re-sensitive to GSH-targeting therapy following VRK2 inhibition, indicating genetic aberrance of VRK2 expression stratifies the response of PC to metabolism-targeted therapies