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Flow cytometry (FACSCantoII, BD Biosciences, San Jose, USA) was used to analyze at least 10,000 cells per sample in duplicates which were categorized by size and granularity into PMN and PBMC ( Supplementary Figures 1A, E )
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The therapy reduced DNA damage and suppressed the transcription of cell death genetic factors Bax, Bcl-2, and caspase-3 in the brains of PD mice (Eleiwa et al., 2023)
The peptide appears to activate genes associated with tissue remodeling while suppressing genes linked to inflammation and tissue breakdown
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