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The apo-peptide (GHK without copper) shows significantly reduced activity in most research models

[23] Severe hypersensitivity reactions including anaphylaxis are exceedingly rare but represent absolute contraindications to rechallenge

IGF-1 levels are also highly influenced by nutritional intake, which might hold greater significance from an evolutionary standpoint, as the primary signaling pathways triggered by IGF-1 in metazoans were originally activated by nutrient availability (34)

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[DOI] [PubMed] [Google Scholar] Shankar V, Thekkeettil V, Sharma G, Agrawal V