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PGF2 inhibits PI3K/AKT in luteolysis which leads to decreased progesterone production and enhanced apoptotic signals

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Qiu YL, Sekiguchi Y, Imachi H, Kamagata Y, Tseng IC, Cheng SS, Ohashi A, Harada H (2004) Identification and isolation of anaerobic, syntrophic phthalate isomer-degrading microbes from methanogenic sludges treating wastewater from terephthalate manufacturing

Well, they're not exactly taking the punch away