The mechanism of action of NAD+ replenishment has been somewhat clarified by research on progeroid (premature aging) disorders, which resemble the clinical and molecular aspects of aging
Keep an eye on how your treatment is going and change it if needed
context and safety matter more
It also means allergic reactions are unlikely, though not impossible, since any foreign substance can theoretically trigger sensitivity in susceptible individuals
Impairment in Glutathione peroxidase 4 (GPX4) function, which attenuates cellular redox defense, i s also associated with cartilage extracellular matrix (ECM) damage (Miao et al., 2022) implying targeting ferroptosis as a promising new direction for possible interventions in OA pathogenesis
Given that the gutskin axis is highly individualized, this is not something to dismiss entirely