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The S1 pocket, which is substratespecific, is highly hydrophobic (Figure 3a) with residues such as Tyr631, Val656, Trp659, Tyr662, Tyr666, and Val711 [40]

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Further case reports of the use of semaglutide to achieve target BMI for patients with ESKD pre kidney transplant have shown the potential for tolerability and therapeutic success[54]