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Note that just the pressure would be lowered

Med Clin North Am 2021;105:9831016.ArticlePubMed 67

4.7 Mineralocorticoid receptor antagonists As we have discussed earlier, the activation of MR plays a crucial role in the pathogenesis of DKD

While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)

It: Binds approximately 7590% of circulating IGF-1 Regulates how much IGF-1 is bioavailable (free to act on tissues) Is produced primarily by the liver, in response to growth hormone signaling - with IGF-1 serving as a key mediator of GHs effects on tissue growth and development Think of IGFBP-3 as a traffic controller: it determines how much of IGF-1s potent growth signal reaches your cells