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Nrf2 appears to play an important role in protecting cancer cells from green tea polyphenol mediated oxidative stress

clinical studies are mostly cross-sectional and correlative, lacking stratification by dose, time window, and tissue source, as well as dynamic follow-up to support testable mechanistic inferences

Instead, she advocates for a more personalized, clinically-informed dosing strategy that emphasizes long-term metabolic health over quick fixes

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Pancreatitis appeared in early animal studies, triggering concerns about long-term pancreatic safety

"The clinical trials show that those on the drug develop pancreatitis more than those on the placebo and it's likely that because this drug acts on the pancreas that it could be causing inflammation." "It's important to say it is very rare and it speaks to the need for people on these drugs to speak to their GP if they're getting it privately or to get it through reputable avenues," he added