It also altered the phosphorylation of ERK, c-Jun N-terminal kinase (JNK), and Akt in hyperglycemic HepG2 cells and reduced the hyperglycemia-induced activation of P38, which is related to high glucose-induced ROS-mediated suppression of growth (Table 2) [114117]
GR activity was expressed as nM NADPH oxidation min 1 mg 1 protein
189 Although DHA is known to slightly elevate LDL levels, high-dose DHA has been shown to increase LDL turnover and LDL particle size 190 (larger LDL particles may not promote atherosclerosis as much as small LDL particles)
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