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In some embodiments, otic formulations or compositions described herein increase the bioavailability and/or steady state levels of a drug in auris structures (e.g., in inner ear and/or the endolymph and/or the perilymph)

especially, at 20 mM, the resulting A 620 of d-carnitine was close to that of l-carnitine

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Determine total peptide needed first: if your protocol calls for 5mg daily for 30 days, you need 5 30 = 150mg total

Supernatants were removed and 100 L of DMSO was added to each well to solubilize the formazan crystals

Acknowledgements Authors want to thank American Centre of Reproductive Medicine for providing support for the study