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Description

Deamidation can trigger aggregation

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8/26/22 weight 214, BMI 36.7 9/29/23 weight 145, BMI 25.0 21lbs weight loss 70lb Weight Loss over 13 months

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33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)

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The reason is pharmacological synergy

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