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In SURMOUNT-1, a 72-week trial, adults on the highest branded tirzepatide dose (15 mg) lost roughly 20%

I have some patients who are seeing me from locations where it would have taken them hours to drive in for a clinic visit

Baseline weight, metabolic status, tolerability, trial design, and treatment duration all shaped how participants responded to different dosages

The company expects to provide results from a 68-week study in people with obesity and osteoarthritis of the knee in 2025, according to fourth-quarter earnings slides on its website

Dose changes and pauses route through the messaging thread before refills, and the care team responds in the same channel

This is relevant for the short-acting GLP-1 agonists, whereas tachyphylaxis rapidly develops for the long-acting agonists [8]