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3 GSH acts as a cofactor of GPX4, promoting the cellular reduction of phospholipid peroxides (PLOOHs) to non-toxic phospholipid alcohols (PLOHs), thereby alleviating cellular oxidative damage induced by ferroptosis
Mitochondrial replacement therapy (MRT) The two basic methods for performing MRT are maternal spindle transfer (MST) and pronuclear transfer (PNT), which improve reproductive success by transferring the nuclear genome from the affected oocyte (MST) or fertilised egg (PNT) to the donors healthy cytoplasm [46]
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