Tirzepatide as a Dual GIP and GLP1 Receptor Agonist : In contrast, Tirzepatide works as a dual agonist for glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors
10.3389/fendo.2021.675834 [DOI] [PMC free article] [PubMed] [Google Scholar] Xu X., Yi H., Wu J., Kuang T., Zhang J., Li Q., et al
furthermore, the risk increases with longer treatment durations, higher doses, and when these agents are used for weight loss
Recently, the inactivating mutation of the tumor-suppressor gene PRKAR1A was found in about 50% of Carney complex cases [ 3 , 4 ]
The PlexusDx Precision Peptide Genetic Test, available as a $99 add-on after your first month of treatment, identifies key genetic variants such as GLP1R rs6923761 and GIPR rs1800437 that influence how quickly you respond to GLP-1 therapy
PMID 25457918.