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[109] However, some patients may experience sleep disturbances or vivid dreams with bedtime dosing, necessitating adjustment of administration timing

Additionally, the high cost of these medications and potential issues with long-term adherence in real-world settings may impact the feasibility of indefinite treatment

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The brain, being a very important organ responsible for managing the affairs of other body functions, interfaces with the body through the BBB, which as described earlier above, selectively permits materials in and out of the brain

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But the same 2025 review that catalogs those effects also underscores that only three human clinical trials have been published and that the compound remains investigational, with regulators having flagged it precisely because human safety and efficacy are not established