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Clinical trials for both mazdutide and retatrutide have not shown elevated rates of pancreatitis, but the sample sizes and durations are still relatively small compared to the decades of post-market surveillance available for older medications

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But in the short run, GI side effects like Nausea, vomiting, and diarrhea can leave you dehydrated, and dehydration can cause a temporary drop in kidney function that shows up as a rising creatinine and a falling eGFR