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Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults

NBP133523 Supplier Novus Biologicals Supplier No

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Depletion of cellular GSH by using buthionine sulfoxamine (BSO), which inhibits glutamatecysteine ligase (the rate-limiting enzyme for GSH synthesis) is sufficient to induce ferroptosis due to impaired cellular antioxidant capacity 18

Discussion TNBC cells overexpress SLC7A11 , which is thought to promote cell survival under OS conditions by sustaining a high rate of GSH synthesis [20]