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In rats, LPS-induced elevations in plasma CRP, tumor necrosis factor-alpha (TNF-), and IL-1 levels are associated with increases in blood pressure

Subcutaneous may offer slightly more consistent plasma levels, but the practical difference is marginal given the compounds short half-life requiring daily dosing either way

J Gen Virol 99(12):16581670 Kerur N et al (2013) TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy

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The BACH1 stabilization mechanism is notable because BACH1 has been reported as an inhibitor of angiogenesis elsewhere