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Autoimmune gastritis (AIG), as a non-self-limiting chronic inflammatory disorder, leads to the destruction of parietal cells in the stomach, resulting in reduced acid output and loss of intrinsic factor, that results in malabsorption of vitamin B 12 and iron, which cause pernicious anemia and iron deficiency anaemia
On the other hand, B12 has been shown to slow down the replication of the hepatitis C virus
This decline correlates with visible aging signs, reduced wound healing capacity, and decreased tissue regeneration, providing the rationale for supplementation