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3 Department of Analytical Medicine Pomeranian Medical University of Szczecin, Szczecin, Poland Correspondence: Elbieta Cecerska-Hery, Email [email protected] Introduction: Oxidative stress (OS) occurs when there is an imbalance between reactive oxygen species (ROS) production and the bodys ability to neutralize them

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80,81 However, subnormal ALP levels are not specific to this condition and can also be seen in other liver diseases

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Sleep is an active biologic process that helps regulate many of the brain's most essential functions, including: Memory consolidation strengthening learning and long-term memory Synaptic plasticity maintaining healthy neural connections Glymphatic function clearing metabolic waste from the brain Neurovascular integrity supporting healthy blood flow & brain function Circadian alignment coordinating the brain's physiologic rhythms A recent review in Seminars in Neurology also highlights that subtle sleep disturbances may precede stroke, Parkinson's disease, Alzheimer's disease, and other neurodegenerative disorders years before clinical symptoms appear, creating an important opportunity for earlier recognition and intervention