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In ICH, the initial injury by the rupture of vessels and the compression of the expanding hematoma is mostly followed by secondary damage, which involves hemoglobin cytotoxicity, microglial activation, and inflammatory cell infiltration in the perihematomal region (Yang et al., 2020)

As an alarming finding, the activation of GLP-1R has been associated with developing thyroid cancer [64, 65]

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therefore dosing intervals should be staggered or alternative non-sedating antihistamines selected