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Patients with liver problems: The medication should also be used cautiously in patients with liver problems, necessitating regular monitoring of liver function

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Patient researchers who respect the titration schedule generally report much better experiences than those who try to accelerate to higher doses

The programme spans multiple trials targeting distinct endpoints: On 21 May 2026 Eli Lilly reported topline results from TRIUMPH-1, the pivotal Phase 3 obesity trial and the programme's first Phase 3 efficacy readout: in 2,339 adults, mean weight loss at the 80-week primary endpoint reached 19.0% (4mg), 25.9% (9mg), and 28.3% (12mg) versus 2.2% for placebo (Eli Lilly investor release

[4] This framework is governed by MHRA guidance on the supply of unlicensed medicinal products