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No documented serious adverse events in the available research, though long-term human data is still limited

Pregnant and breastfeeding women should consult healthcare providers before starting any new supplement regimen

Barros et al., 2008)

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Examples include: Certain antidepressants such as Effexor (venlafaxine), Pamelor (nortriptyline), and selective serotonin reuptake inhibitors (SSRIs) such as Paxil (paroxetine), Prozac (fluoxetine), or Zoloft (sertraline) Antipsychotics such as Haldol (haloperidol) and Risperdal (risperidone) Beta-blockers such as Lopressor (metoprolol tartrate), Toprol XL (metoprolol), or Inderal (propranolol) Type 1C antiarrhythmics such as propafenone or flecainide Drugs that increase the risk of seizures Bupropion lowers the seizure threshold, making it more likely that a seizure will occur

Nausea 15-44%, vomiting 5-24%