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Symptoms : Weight loss, heat intolerance, anxiety, palpitations, and ophthalmopathy (exophthalmos)

Researchers examine it to understand peptide copper interactions, matrix related biochemical activity, and broader sequence specific signalling mechanisms under controlled conditions

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As an added precaution for patients with a reaction history within the previous five years, which makes them higher risk, a two-step DOC, starting with 10% of the target dose, is recommended