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3.4 Adverse events Three subjects experienced intermittent diarrhea, bloating and nausea before the initiation of semaglutide treatment (timepoint 1), but the symptoms were not severe enough to warrant discontinuation of metformin therapy

Commercial plans more often cover GLP-1s for type 2 diabetes than for obesity alone, often requiring prior authorizations

Other gastrointestinal DPP-4 substrates are pancreatic peptide YY and neuropeptide Yboth bind to the same receptors and appear to increase bone resorption and decrease bone formation

Disadvantages: Different mechanism, no copper delivery

Medicina 60 , (2024)

The leptin receptor is expressed on most GALP neurons and expression of GALP in the ARC is induced by leptin