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In summary, GLP-1 receptor agonists exert anti-fibrotic effects in MASLD through the inhibition of hepatic stellate cell activation, the modulation of profibrotic signaling pathways, and the promotion of hepatocyte regeneration

Insulin Secretion and Sensitivity Apart from stimulating insulin release, GLP-1 suppresses the secretion of glucagon, a hormone that increases blood glucose levels by promoting gluconeogenesis and glycogenolysis in the liver

however, in other infusion studies with the GLP-1 receptor agonist exenatide, measured GFR (mGFR) was increased in healthy volunteers (26) and unchanged in people with T2D (30)

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Both drugs carry a boxed warning for thyroid C-cell tumors based on rodent data

Its multi-receptor interaction profile makes it relevant for investigations involving ligand-receptor specificity and coordinated signaling mechanisms