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GLP-1 receptor agonists aid in weight loss by suppressing appetite signals in the brain and promoting feelings of fullness, leading to reduced food intake

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(source) A 2017 meta-analysis did not support the suggestion that treatment with GLP-1 agonists or DPP-4 inhibitors increased all-cause mortality in type 2 diabetics

Butyrate is associated with a spectrum of health benefits including healthy blood sugar response, gut permeability, and immune function

Moving from GLP-1 to insulin Conversely, some patients on GLP-1 therapy may eventually need insulin if their Type 2 diabetes progresses and beta cell function declines further