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Endogenous GLP-1 alters postprandial functional connectivity between homeostatic and reward-related brain regions involved in regulation of appetite in healthy lean males: A pilotstudy

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Furthermore, important questions remain, including the long-term durability of weight loss and its maintenance after treatment discontinuation, as well as its impact on major cardiovascular outcomes

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Accordingly, the prevention of declining leptin levels via exogenous leptin treatment attenuates starvation-induced suppression of gonadal and thyroid axes in mice and humans 1, 3