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Microbial BMAA and the pathway for Parkinsons disease neurodegeneration

In: ChakrabortiSRayBKRoychowdhuryS, editors

The iron-overload state commonly observed in AD brains exacerbates neuronal oxidative damage and, through the release of pro-inflammatory mediators and activation of immune cells, contributes to the structural disruption of the BBB

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Research on skeletal muscle biopsies from DMD patients has revealed decreased NAD + levels, increased PARP activity 253 and dysfunction of mitochondrial metabolism 254,266