GLP-1 agonists are thought to flip that switch back to the OFF or at minimum, act as a dimmer switch to tone down the intensity of the ON signaling thereby reducing the production of inflammatory cytokines
Short-acting agents like exenatide often cause more gastroparesis (slow gastric emptying), while long-acting ones like dulaglutide may be better tolerated
If you cannot keep fluids down due to concurrent nausea, seek medical attention
Animal studies and small human trials have shown similar trends, and this new study builds additional evidence with larger and more generalizable real-world populations
Delivery methods other than injections and oral pills, such as sublingual drops and dissolving tablets, have not been tested in clinical trials
Still, this combination also introduces potential challenges: Potential for low blood sugar: Because GLP-1 medications affect insulin sensitivity and digestion, prolonged fasting can lead to fatigue, dizziness, or hypoglycemia
