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Using a BBB spheroid model consisting of HBPCs, HASTRs and human brain microvascular ECs (HBMECs), they further elucidated that Gpr183 activation with 7,25-OHC led to reduced VE-cadherin expression, a key component of endothelial junction integrity

In an aging brain, oxidative stress is a major contributing factor to chronic inflammation, leading to cognitive impairment, memory issues, or more serious manifestations

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Verdict: Direct comparison difficult due to different trial designs, but retatrutide's advantage appears substantial even accounting for flexible vs fixed dosing