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Statements Author contributions BG: Writing original draft

Several factors contribute to these elevated costs: Patent protection Most GLP-1 medications are still under patent, preventing generic competition Manufacturing complexity These are biologic medications that require specialized production processes Research and development costs Pharmaceutical companies invest heavily in clinical trials and regulatory approval Market positioning These medications are often priced as premium treatments Without insurance coverage, patients face the full retail price, which can make these medications financially inaccessible for many people who need them

Here are the vectors of innovation that players are currently focused on: GLP-1 innovation vector (1): Drug design and formulation Next-generation molecules aim to improve both efficacy and convenience

Some patients may experience rebound effects or find that their bodies develop resistance to the medication

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