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6 Beyond their metabolic effects, recent studies suggest that GLP-1 RAs may have central nervous system activity and anti-inflammatory properties, making them a potential therapeutic option for conditions like IIH

Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively

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Thus far, the binding poses of two full-length peptide-bound, active GLP-1R structures 3,4 and an active-like structure with a truncated peptide agonist (peptide 5) 12 have been detailed, as well as variable ligand-dependent ECD receptor conformations