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In a study examining the impact of increased physical activity through a home-based exercise program on biomarkers in stage IIIII CRC patients, the baseline level of IGFBP3 was 2.67 1.48 g/ml, with a p-value of 0.013 for the effect after 12 weeks of activity [45]
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Side effects were mainly mild-to moderate gastro-intestinal symptoms (nausea, vomiting, diarrhoea) mostly occurring with higher doses of retatrutide and with faster titration (Table 2)
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However, a minority of patients experience persistent gastrointestinal symptoms that do not adequately resolve over time
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