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The risk to the fetus is placental failure leading to growth retardation and preterm birth with poor nephron endowment, which is associated with the risk of developing hypertension and kidney disease later in life (see also above) 58

In PIONEER 4, additional anti-diabetic medication and rescue medication use was more than double in the placebo treatment group compared to the semaglutide 14 mg and LIRA 1.8 mg treatment groups

Some supplements and over-the-counter (OTC) drugs can interact with semaglutide

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