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This combination produced weight loss exceeding 24% of body weight in clinical trials, substantially outperforming dual agonists like tirzepatide
The unique advantage of retatrutide, its ability to increase energy expenditure and fat oxidation beyond what GLP-1/GIP alone achieve, may depend on reaching peak concentrations that only weekly dosing reliably provides
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Dawkins says, Since the GIP [glucose-dependent insulinotropic polypeptide] hormone acts as an antiemetic, the dual agonist tirzepitide is associated with fewer adverse side effects and better tolerance. References 1
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