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In vitro and in vivo models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expressions of GCLC, GCLM and SLC7A11 were down-regulated, thereby disrupting the metabolism of glutathione
AHK-Cu reduced PARP cleavage fragments by 77.5%, confirming reduced cell death
10.1016/s0928-4257(97)89474-0 120 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.JagicV.et al (1997a)
But if you want to give it a try, you can move ahead with your discretion, as it poses no threat to your skin and overall health
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