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Considering microenvironments in and around malignant tumours, the haem concentration in cancer cells is likely to be elevated through multiple mechanisms, such as (i) an increased intake of haem, (ii) mutation of enzymes in TCA cycle (for example, fumarate hydratase) that increases the level of succinyl CoA, a substrate for haem biosynthesis and (iii) metastasis to haem-rich organs such as liver, brain and bone marrow 46,47,48

Meschede, D

Large retrospective cohort studies showed that cognitive impairment is the first sign and a trait marker in individuals later diagnosed with schizophrenia (Rund, 1998)

Alcohol contains empty calories and may impair weight loss efforts

Research progress of glucagon-like peptide-1 (GLP-1) analogues [J]