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Many studies have shown that CYPs typically have a high deuterium KIE for hydrogen abstraction, which means that the water molecule will be deupleted

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Biochemist 28:3133 Bulley SM, Rassam M, Hoser D, Otto W, Schnemann N, Wright M, MacRae E, Gleave A, Laing W (2009) Gene expression studies in kiwifruit and gene over-expression in Arabidopsis indicates that GDP-L-galactoseguanyltransferase is a major control point of vitamin C biosynthesis