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Morton JI, Marquina C, Shaw JE, Liew D, Polkinghorne KR, Ademi Z, et al

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Furthermore, growing evidence suggests that the dysbiosis of the gastrointestinal tract may eventually contribute to the impairment of intestinal mucosal integrity, instigate a high-level inflammation response, affect the bile acids cross-talk, and disrupt minerals absorption ratethereby, hastening the evolution of OP

A multi-center phase-II clinical trial, started a few years ago to investigate the biological and clinical effects of rapamycin in people with ALS, is currently underway and will provide important information for further potential trials [312], thus opening new therapeutic perspectives for ALS