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Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

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Pathway-level genetic context is the upstream variable underneath every protocol choice

Al-Brakati A, Alsharif KF, Alzahrani KJ, Kabrah S, Al-Amer O, Oyouni AA, Habotta OA, Lokman MS, Bauomy AA, Kassab RB, Abdel Moneim AE (2021) Using green biosynthesized lycopene-coated selenium nanoparticles to rescue renal damage in glycerol-induced acute kidney injury in rats

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Entering the era of genomics, proteomics and lipidomics, it will be clear that the complete story is not yet told