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One challenge will be for these results to sway the thousands of providers who are hesitant to prescribe injection agents to adolescents with obesity

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Occasionally, authors may express opinions that represent their own viewpoint

We believe that the mechanistic pathways uncovered here have potential for impact in the clinical context of IRI, for which no approved therapies currently exist

Additionally, we discuss the impact of AOX therapy on fertility outcomes in men and women under natural and assisted reproduction conditions