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Engeletin, a flavonoid from Smilax glabra , suppressed Toll-like receptor 4-NF-B signaling, reduced the expression of IL-1, IL-6, and TNF-, and inhibited macrophage polarization from the pro-inflammatory M1 phenotype

This interaction is significant in research exploring calmness, sleep induction, and nervous system regulation

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A primary mechanism is its profound influence on gene expression

Nature (2006) 440(7081):23741