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Both compounds are developed by Eli Lilly, both target GLP-1 and GIP receptors, but Retatrutide adds a third receptor glucagon creating a triple agonist with superior weight loss results in clinical trials

Side effects, dosing, and drug interactions vary significantly between these medications

Cell Death Differ (2022) 29(9):1790803

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PMID:1658407 [5] Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME

This interspecies variability, particularly among ants, bees, and humans, suggests that the PAS position may contribute to differential ligand recognition and should be considered in the design of insect-selective AChE inhibitors ( Table 5 )