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It is released by damaged collagen as a biological signal for repair

Rishniw and Brown warn that such breeds as the CKCS "likely require breed-specific reference intervals for LVIDDN to correctly identify left ventricular enlargement." Specifically for the 59 cavaliers in the study, they determined that the upper limit for normal-sized LVIDDN should have a scaling exponent of 0.33 (compared to EPIC's and ACVIM's arbitrary, species-wide exponent of 0.294), and that the range of LVIDDNs derived using 0.33 would be from 1.62 to 1.71 with a mean of 1.69