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330 Studies have shown that the modulation of miRNA expression can alleviate the symptoms of UC via in vitro and in vivo experiments, which provides hope for the application of miRNAs in UC treatment

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J Biol Chem 1999;274:19228-19236

Notwithstanding progress in stabilizing RNA molecules and augmenting their on-target efficacy, the primary problem is still in developing safe and highly effective strategies for endosomal escape to deliver RNA therapies into the cytoplasm for functional action

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Joint pain limits exercise, reduced activity leads to more weight gain, and the cycle continues