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Small, frequent sips of water, electrolyte solutions, or clear broths can help maintain hydration when nausea limits intake

It improves insulin sensitivity, modestly reduces appetite, and produces a small amount of weight loss (typically 2 to 5 percent of body weight)

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spreading it out over the week improves tolerance

Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight

Sleep hygiene Glycine improves sleep quality, but it works best when combined with good sleep hygiene practices